The 49ers have been bombarded with injuries this year, but they’ll get a bit of relief. San Francisco has officially made the move to activate safety Talanoa Hufanga from injured reserve. After attempting to make a comeback earlier this year, the hope is that, this time, Hufanga will be healthy enough and here to stay.

Hufanga’s initial return was from a torn ACL that he suffered just over a year ago. The team activated him from the active/PUP list just prior to the start of the regular season to ensure that he wouldn’t miss the first four games of the year. A limited runup to the season meant a limited snap share when he finally did return to the lineup, though, and after missing the first two games of the season, Hufanga made his official return in Week 3.

Hufanga missed a game after his 2024 debut before getting his second start, but he left that second game early and did not return. In the process of his comeback, Hufanga had suffered ligament damage in his wrist, necessitating an unfortunate return to IR. There was seemingly no guarantee that he would return this season, but the team ended up opening his practice window earlier this week. Hufanga, who is in a contract year, will not be 100 percent in his return as he still needs support for his injured wrist. With a potential free-agency run coming, though, Hufanga will attempt to give it a go.

In order to make room on the 53-man roster for Hufanga, the Niners officially made the move to place running back Jordan Mason on IR. Joining Mason on IR will be backup safety George Odum, who has missed the past week of practice dealing with a knee issue that will seemingly end his season.

With an additional roster spot being made available, San Francisco will sign practice squad offensive tackle Sebastian Gutierrez to the active roster. Signed to the practice squad last week after some time in Indianapolis, Gutierrez was elevated for last weekend’s contest but hasn’t appeared in a game since 2022.

Joining Gutierrez for gameday from the practice squad will be linebacker Jalen Graham and running back Ke’Shawn Vaughn. As standard practice squad elevations, Graham and Vaughn will revert to the practice squad after the game, while Gutierrez will remain on the 53-man roster.