The San Francisco 49ers continue to battle the injury bug as they enter the final stretch of the 2024 season. With their playoff hopes hanging a by thread, the team must win out and have every domino fall their way. A task harder to do following head coach Kyle Shanahan’s injury announcement before Wednesday’s practice ahead of a Week 16 matchup vs. the Miami Dolphins.

Running back Isaac Guerendo, who was already playing through a foot sprain, will not practice after suffering a hamstring injury in the loss vs. the Rams last week. Guerendo has served as the team’s starter for the last two weeks after season-ending injuries to Christian McCaffrey and Jordan Mason.

The rookie running back has carried the ball for 135 yards and two touchdowns in 31 attempts while hauling in six receptions for 68 yards as a receiver. Shanahan did not specify Guerendo’s status for this Sunday’s game but gave a discouraging update for left tackle Trent Williams’ return.

Trent Williams Season Over?

“If he could get back to healthy, we’d play him, but it’s not like that right now,” said Shanahan when asked if Trent Williams is not going to play the rest of the season. “So it’s getting closer to being that way.”

Williams is still nursing an ankle and heel injury he suffered in the team’s Week 11 loss vs. the Seattle Seahawks on November 17th. In Williams’ absence, San Francisco has given up 39 total pressures, per Pro Football Focus. The team has also seen their playoff odds drop below one percent. Without Williams this season, the 49ers have a 1-3 record.