The Detroit Lions are looking to finish their regular season road slate a perfect 8-0 on the year as they square off against the San Francisco 49ers in Santa Clara in a rematch of last year’s NFC Championship Game.

Here are five things to watch out for in tonight’s contest:

1. Playoff scenarios

As expected, the Minnesota Vikings kept up their winning ways, beating Green Bay at home Sunday afternoon to set up a winner-take-all matchup between the Lions and Vikings Week 18 in Detroit for the NFC North title and the No. 1 overall seed in the NFC playoffs, no matter what happens in Detroit’s game with San Francisco tonight.

That being said, Lions head coach Dan Campbell said they came out to California to win and they will do so with all the resources available to them. There’s also this to consider: If the Lions lose to the 49ers tonight, then in a rare case of a tie next week, the Vikings win the division. If the Lions beat the 49ers, a tie next week goes in Detroit’s favor. It may be improbable, but it’s nice to have that tiebreaker in your back pocket.

2. Passing attack on point

It’s a terrific matchup this week with a historically good Lions offense’ facing off against a pretty stingy 49ers’ defense. Detroit has already set franchise records in points scored (493), touchdowns (61) and are 584 yards away from setting the record for the most total net yards in a season. Quarterback Jared Goff and the Lions’ passing attack rank No. 2 as Goff has produced 11 games this season with a passer rating north of 100.0.

The 49ers’ defense has allowed the second fewest yards per game (304.3) and third fewest passing yards (183.3). San Francisco’s pass defense is holding opponents to 6.6 yards per pass attempt this season, the third lowest in the NFL behind Philadelphia (6.2) and Houston (6.5). Can Goff and the offense keep it rolling in the pass game?

3. Red zone

If there’s one distinct advantage the Lions have heading into tonight’s game with the 49ers it’s their play on both sides of the ball in the red zone. The 49ers have the No. 2 total defense in football but rank just 19th in scoring defense (23.2 points allowed), partly because they have the fourth worst red-zone defense in the NFL with opponents scoring a touchdown 65.3 percent of the time in the red zone.

On the flip side, San Francisco’s offense ranks just 25th in the red zone (51.8) vs. a Lions’ defense that is seventh best at keeping teams out of the end zone in the red zone (50.0). Who can turn those red zone trips into touchdowns more often?

4. 49ers defenders

San Francisco has suffered a number of significant injuries on offense, but their defense has remained mostly intact. It features some All-Pro players on that side of the ball who can impact the game and who the Lions have to keep an eye on.

Linebacker Fred Warner has registered 117 tackles, seven passes defended, four forced fumbles, a sack and two interceptions with one returned for a touchdown. His 28 passes defended over the last three seasons are the most by any linebacker in the NFL.

Defensive end Nick Bosa has 44 tackles, 7.0 sacks, one interception, one forced fumble and a fumble recovery. His 60.5 career sacks are the third most in 49ers history.

“Of course, yeah, those two guys are great players, All-Pro players, played them for a long time now,” Goff said this week. “They’re great players, they’re tough to beat every week you play them and those two guys in particular, you have to be aware of where they are and as well as a bunch of the other guys on defense.”

Leonard Floyd is another name to watch out for as he’s leading the 49ers with 8.5 sacks on the year.

5. Limiting big plays

Despite the injuries San Francisco’s offense has dealt with, they are still one of the most explosive teams in the league with players like George Kittle, Deebo Samuel and Jauan Jennings who can make big-time plays if the Lions let them.

San Francisco has registered 56 receptions of 20-or-more yards this season, which is third most in the NFL behind only Detroit (57) and Minnesota (57). The 49ers’ offense has gained 5,486 total net yards while their defense has allowed 4,564 total net yards. Their plus-922 differential is better than all but three teams: Philadelphia (1,337), Baltimore (1,285) and Detroit (1,046). Detroit’s new-look secondary will be tested again this week.